Yohimbol (Yohimbine HCl 5 mg)

Yohimbol (Yohimbine HCl 5 mg) is Evolve Biolabs' alpha-2 adrenergic antagonist, supplied as 100 tablets in sealed blister strips. It is derived from the bark of the yohimbe tree and has been studied for both sexual function and fat metabolism.

What Yohimbol Is

Yohimbine is an indole alkaloid obtained from Pausinystalia yohimbe, a tree native to West and Central Africa. It acts as an antagonist at alpha-2 adrenergic receptors, blocking the negative feedback that normally limits noradrenaline release. That mechanism raises sympathetic outflow, which is the basis for its effects on erectile tissue and on lipolysis. Yohimbol supplies 5 mg of yohimbine hydrochloride per tablet across 100 tablets.

The History of Yohimbine

Yohimbine was isolated from yohimbe bark in the late nineteenth century and entered medical use as a treatment for erectile dysfunction. It was one of the few pharmacological options available for that indication before the PDE5 era, and it remains the subject of clinical research. The compound has also been used in veterinary medicine as an alpha-2 antagonist, and it appears in the literature on autonomic pharmacology and fat metabolism.

How It Works

Yohimbine blocks presynaptic alpha-2 receptors, preventing the feedback inhibition of noradrenaline release. The resulting increase in sympathetic tone affects vascular smooth muscle and adipose tissue. In erectile tissue, the effect is thought to involve both central and peripheral pathways. In fat cells, alpha-2 blockade removes an inhibitory brake on lipolysis, which is why yohimbine has been studied as a fat-loss adjunct. The drug is metabolised in the liver and has a relatively short half-life.

What the Research Shows

• Yohimbine has been studied clinically for erectile dysfunction.
• Research shows alpha-2 blockade increases noradrenaline release and lipolysis.
• Trials have examined its effects on fat loss, with mixed results.
• Anxiety, hypertension and tachycardia are documented at higher doses.

Research Context

Yohimbine's research profile is split between sexual function and metabolism. In erectile dysfunction it was studied before PDE5 inhibitors existed, and it remains a comparator in autonomic pharmacology. In fat-loss research it has been examined as an adjunct to caloric restriction, with results that vary considerably between individuals. Its stimulatory effects on the sympathetic nervous system are the main safety consideration, and they explain why anxiety and cardiovascular responses are recurring endpoints.

Strength, Pack and Authentication

Each tablet contains 5 mg of yohimbine hydrochloride, with 100 tablets per pack. The tablets are sealed in moisture-resistant blister strips inside a printed, tamper-evident carton stating the compound, strength and tablet count. A verification code on the packaging can be checked against Evolve Biolabs' records, and the blister format protects each tablet from moisture and light.

Buying Yohimbol Online

Yohimbine is one of the most searched alpha-2 antagonists. If you are researching yohimbine HCl, comparing 5 mg yohimbine products or looking to buy Yohimbol online from a verified Evolve Biolabs supplier, this page gives you the full specification, pack size, price and live stock status. Browse more Evolve Biolabs products at NotNatty.