Aromasin (Exemestane)

Exemestane, sold as Aromasin, is a steroidal aromatase inhibitor, and that distinction matters more than it sounds. Because it binds to the aromatase enzyme irreversibly, the body has to synthesise new enzyme to recover - which gives it a longer, more even effect than the reversible inhibitors like anastrozole.

When it is preferred

The steroid structure means it is less likely to worsen the lipid profile, which is one of the main reasons people switch to it. The trade-off is that it is dosed less frequently - a few times a week rather than daily - and it is more expensive. The same warning applies as with any AI: it will happily over-suppress estradiol, and the symptoms of that - joint pain, mood flatness, low libido - are the reason to titrate rather than hammer it.

Checks

• Label names exemestane and mg per tablet - genuine Aromasin is 25mg.
• Sealed bottle, printed batch and expiry, tablets intact.
• Store cool and dry, away from pets and children.
• Not to be confused with anastrozole; the two are not interchangeable at the same dose.

Quick answers

Aromasin or Arimidex?

Aromasin is steroidal and irreversible - it keeps working after levels drop, so dosing stays spaced (12.5-25 mg every other day) and overshoot lasts longer. Arimidex is reversible and fast-clearing, which makes it more forgiving for first-timers. Full trade-offs in the AI comparison.

Can aromasin crash estrogen permanently?

Not permanently - it clears in days and your body makes new enzyme - but the crash feels longer than arimidex's because of the irreversible mechanism. Dose spacing is the safety net; the exemestane guide covers split-tablet math.

Does aromasin need food?

Yes - it absorbs noticeably better with a fat-containing meal. Take it after eating, not on an empty stomach.