Sildenafil (Viagr-ON) 100 mg

Sildenafil (Viagr-ON) 100 mg is Hilma Biocare's fast-acting PDE5 inhibitor, supplied as 10 tablets. It is the original erectile-function medication and the benchmark against which every later PDE5 inhibitor is measured.

What Sildenafil Is

Sildenafil is a selective phosphodiesterase type 5 inhibitor that prevents the breakdown of cyclic GMP in vascular smooth muscle. Nitric oxide released during sexual stimulation raises cGMP, and with PDE5 inhibited the signal persists, producing relaxation and increased blood flow. Sildenafil is fast-acting, with onset typically within 30 to 60 minutes, and its effect lasts around four to six hours. The 100 mg tablet is the standard clinical strength.

The History of Viagra

Sildenafil was developed by Pfizer in the 1990s as a treatment for angina. During trials, participants reported an unexpected effect on erectile function, and Pfizer pivoted the programme. The drug was approved in 1998 as Viagra and became a cultural phenomenon, selling millions of tablets in its first year. It transformed the treatment of erectile dysfunction and opened the PDE5 class.

How It Works

Sildenafil binds PDE5 and blocks the degradation of cGMP in the corpus cavernosum. With nitric oxide signalling intact, smooth muscle relaxes and blood flow increases. The drug is metabolised in the liver by CYP3A4 and excreted mainly in bile and urine, with a half-life of around four hours. Its relatively short duration is the main pharmacokinetic difference from tadalafil.

What the Research Shows

• Clinical trials established sildenafil's efficacy for erectile dysfunction.
• Studies show onset within an hour and a duration of four to six hours.
• Sildenafil has also been studied for pulmonary arterial hypertension.
• Cardiovascular effects and drug interactions are well characterised.

Research Context

Sildenafil's selectivity for PDE5 over other phosphodiesterases explains both its effects and its side effects. PDE6 in the retina is partially inhibited, which can produce temporary blue-tinted vision, and PDE11 inhibition may account for some musculoskeletal complaints. The drug's interaction with nitrates is absolute: combining them can cause severe hypotension. Research has also examined sildenafil in pulmonary arterial hypertension, where it improves exercise capacity, and in altitude illness, where it helps with pulmonary oedema. Those areas round out the clinical picture beyond erectile function.

Strength, Pack and Authentication

The pack contains 10 tablets of 100 mg each, sealed in moisture-resistant blister strips inside a printed carton. The carton states the compound, strength and tablet count, and a scratch-off security code inside the box links the pack to Hilma Biocare's records. Each tablet delivers a consistent 100 mg dose.

Buying Viagra Online

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