GONIN 5000 (HCG 5000 IU)

GONIN 5000 (HCG 5000 IU) is Evolve Biolabs' lyophilised human chorionic gonadotropin kit, supplied as one 5000 IU vial with a 1 ml sodium chloride diluent ampoule. It binds the LH receptor and stimulates testicular function, making it a standard tool in fertility and hormone-recovery research.

What GONIN 5000 Is

Human chorionic gonadotropin is a glycoprotein hormone normally produced by the placenta during pregnancy. It consists of alpha and beta subunits; the alpha subunit is shared with LH, FSH and TSH, while the beta subunit gives HCG its specificity for the LH receptor. Because it mimics LH, HCG stimulates Leydig cells in the testes to produce testosterone and supports spermatogenesis. The kit provides 5000 IU of lyophilised powder plus diluent for reconstitution.

The History of HCG

HCG was identified in the late 1920s by Aschheim and Zondek, who found it in the urine of pregnant women and recognised it as a marker of pregnancy. Extracts were used clinically from the 1930s for fertility and cryptorchidism, and HCG became the basis of early pregnancy testing. Purified urinary and later recombinant preparations followed, and the hormone remains a standard in reproductive medicine.

How It Works

HCG binds the LH receptor on Leydig cells and activates the same signalling pathway as luteinising hormone, stimulating the conversion of cholesterol to testosterone. In the testes it supports androgen production and, together with FSH, spermatogenesis. Because it acts directly on the gonads, it can maintain testicular function when pituitary LH output is suppressed. It is cleared by the liver and kidneys with a half-life of roughly a day.

What the Research Shows

• HCG has been studied extensively in fertility treatment and hypogonadism.
• Trials examine its use alongside testosterone therapy to preserve testicular function.
• Its LH-receptor mechanism and dose-response behaviour are well characterised.
• HCG remains a standard in ovulation induction and male fertility research.

Research Context

A recurring finding in HCG research is that continuous exposure can desensitise Leydig cells, which is why intermittent regimens are common in study designs. The hormone's beta subunit is also the basis of many pregnancy tests, a practical application dating back to the 1930s. More recently, researchers have examined HCG as an adjunct to testosterone therapy, where the goal is to maintain testicular volume and function rather than to raise testosterone directly.

Strength, Pack and Authentication

Each kit contains one vial of 5000 IU lyophilised HCG and one 1 ml ampoule of sodium chloride diluent. The vial and ampoule are sealed in a printed, tamper-evident carton stating the compound, strength and storage instructions. A verification code on the packaging links the pack to Evolve Biolabs' records; the powder is stable before reconstitution, and the solution should be refrigerated and used within the recommended window.

Buying GONIN 5000 Online

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