GHRP-2 10 mg

GHRP-2 10 mg is Hilma Biocare's synthetic growth-hormone secretagogue, supplied as a single lyophilised vial. It stimulates GH release through the ghrelin receptor and is one of the most studied hexapeptide secretagogues.

What GHRP-2 Is

GHRP-2 is a synthetic hexapeptide that acts on the growth-hormone secretagogue receptor, also known as the ghrelin receptor. It stimulates pituitary somatotrophs to release growth hormone, producing a dose-dependent GH pulse. Compared with GHRP-6, it produces less appetite stimulation, which is a meaningful difference in research design. The 10 mg vial is the standard presentation.

The History of GHRP-2

GHRP-2 was developed in the 1990s as part of the growth-hormone-releasing peptide programme that began with GHRP-6 in the 1980s. Researchers synthesised a series of small peptides that triggered GH release through a receptor distinct from GHRH. GHRP-2 emerged as one of the most potent and selective, and it became a standard tool for studying the ghrelin system and pituitary function.

How It Works

GHRP-2 binds the ghrelin receptor on pituitary cells and activates phospholipase C signalling, which raises intracellular calcium and triggers GH granule release. It also acts on the hypothalamus to increase GHRH and reduce somatostatin tone. The result is a strong, short-lived GH pulse. The peptide is rapidly cleared, which is why research often pairs it with a longer-acting GHRH analogue.

What the Research Shows

• GHRP-2 reliably stimulates GH release in human and animal studies.
• Research shows a synergistic effect when combined with GHRH.
• Its lower appetite stimulation distinguishes it from GHRP-6.
• The ghrelin receptor mechanism is well characterised.

Research Context

GHRP-2 is frequently studied alongside a GHRH analogue because the two act on different receptors and produce a synergistic GH response. Research shows that combining a GHRP with GHRH can increase GH output several-fold compared with either alone. GHRP-2 also has a modest effect on prolactin and cortisol at higher exposures, which is a consideration in study design. Its lower appetite stimulation relative to GHRP-6 makes it useful when the research question is GH release without a confound from caloric intake. Studies also show that the size of the GH pulse depends on the dose and on the background level of somatostatin, which is why timing and fasting status are controlled in good study designs.

Strength, Pack and Authentication

Each vial contains 10 mg of lyophilised GHRP-2, sealed and packed in a printed carton stating the compound, strength and vial count. A scratch-off security code inside the box links the pack to Hilma Biocare's records. The powder is stable before reconstitution and intended for research use only.

Buying GHRP-2 Online

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