NAD+ 500 mg

NAD+ 500 mg is Hilma Biocare's nicotinamide adenine dinucleotide, supplied as a single lyophilised vial. It is a coenzyme central to cellular energy production and DNA repair, and one of the most researched molecules in longevity science.

What NAD+ Is

Nicotinamide adenine dinucleotide is a coenzyme found in every living cell. It exists in oxidised and reduced forms and shuttles electrons through the mitochondrial respiratory chain, driving ATP production. It is also the substrate for sirtuins and PARP enzymes, which regulate gene expression and DNA repair. The 500 mg vial is a high-strength presentation for extended research.

The History of NAD+

NAD+ was discovered in 1906 by Arthur Harden and William John Young, who found it was required for fermentation. Its role in electron transport was established in the 1930s and 1940s. Interest surged in the 2000s when sirtuins were shown to depend on NAD+, linking the coenzyme to ageing. That connection made NAD+ one of the most studied molecules in contemporary longevity research.

How It Works

NAD+ accepts and donates electrons in redox reactions, allowing the mitochondrial electron transport chain to generate ATP. It is also consumed by sirtuins, PARPs and CD38, which use it as a substrate for deacetylation and ADP-ribosylation. NAD+ levels decline with age, and that decline is thought to impair both energy metabolism and DNA repair. The coenzyme is synthesised from nicotinamide and recycled through salvage pathways.

What the Research Shows

• NAD+ decline with age is documented across species.
• Sirtuin research established NAD+ as a regulator of gene expression.
• Animal studies show that raising NAD+ improves metabolic function.
• Human trials of NAD+ precursors are ongoing and mixed.

Research Context

NAD+ research has shifted toward precursors such as nicotinamide riboside and nicotinamide mononucleotide, which are better absorbed than the dinucleotide itself. Human trials of those precursors show that they raise NAD+ levels, but the effects on clinical outcomes have been mixed. The biology is compelling: NAD+ is required for sirtuin activity, DNA repair and mitochondrial function, and levels decline with age. Researchers continue to debate whether raising NAD+ translates into meaningful health benefits or whether it is primarily a biomarker of cellular state.

Strength, Pack and Authentication

Each vial contains 500 mg of lyophilised NAD+, sealed and packed in a printed carton stating the compound, strength and vial count. A scratch-off security code inside the box links the pack to Hilma Biocare's records. The powder is stable before reconstitution and intended for research use only.

Buying NAD+ Online

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