Epitalon 10 mg

Epitalon 10 mg is Hilma Biocare's synthetic tetrapeptide, supplied as a single lyophilised vial. It is studied for telomerase activation, melatonin regulation and cellular ageing, making it one of the most researched longevity peptides.

What Epitalon Is

Epitalon, also known as epithalamin or AGAG, is a four-amino-acid peptide derived from the pineal gland. Its sequence is alanine-glutamate-aspartate-glycine. Unlike most research peptides, its primary interest lies in gene regulation rather than receptor signalling: it has been studied for its ability to influence telomerase and the expression of ageing-related genes. The 10 mg vial is a high-strength presentation for extended research.

The History of Epitalon

Epitalon was developed by Vladimir Khavinson and colleagues at the St Petersburg Institute of Bioregulation and Gerontology in the 1980s and 1990s, building on earlier work with the pineal extract epithalamin. The peptide was synthesised to isolate the active short sequence and was studied in ageing models and human trials in Russia. Its association with telomerase emerged from research in the early 2000s, which brought it international attention in longevity circles.

How It Works

Epitalon is thought to enter cells and influence gene expression, particularly genes involved in telomere maintenance and the circadian regulation of melatonin. Studies have reported increased telomerase activity in cultured cells and in animal models, although the mechanism is not fully established. The peptide is short-lived in circulation and is typically studied in short courses. Its pineal origin is central to its proposed role in neuroendocrine ageing.

What the Research Shows

• Russian studies examined epitalon in ageing and neuroendocrine models.
• Cell-culture work reported telomerase activation and telomere elongation.
• Animal research has examined melatonin regulation and lifespan.
• Human data is limited and mostly from small trials.

Research Context

Epitalon research is closely associated with the St Petersburg group that developed it, and much of the literature originates from Russian institutions. Studies have examined its effects on melatonin rhythm, antioxidant status and lifespan in animal models, as well as telomerase activity in cell culture. The human evidence is limited to small trials, often with surrogate endpoints rather than clinical outcomes. That is a common limitation in longevity research, and epitalon is a good example of a compound whose mechanistic promise outpaces the available clinical data.

Strength, Pack and Authentication

Each vial contains 10 mg of lyophilised epitalon, sealed and packed in a printed carton that states the compound, strength and vial count. A scratch-off security code inside the box can be verified against Hilma Biocare's manufacturing records. The powder is stable before reconstitution and intended for research use only.

Buying Epitalon Online

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