GHK-Cu 50mg

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding tripeptide that has been a subject of regenerative and dermatological research since the 1970s. Found in human plasma, saliva, and urine, GHK levels decline significantly with age — a finding that has driven interest in its role as a signaling molecule in tissue repair and extracellular matrix remodeling.

This research-grade GHK-Cu is supplied as a blue crystalline powder, independently verified by HPLC-UV (≥98% purity) and LC-MS identity confirmation, with copper content validated by ICP-MS to ensure a consistent 1:1 peptide-to-copper stoichiometry. This is research-grade material — not an unverified cosmetic-grade copper salt.

Proposed mechanisms of interest in preclinical and in vitro literature:

Fibroblast activation & collagen synthesis: GHK-Cu has been shown to stimulate collagen synthesis in human fibroblast cultures, with effects observed at concentrations as low as 10⁻¹² to 10⁻⁹ M. It is studied for its ability to upregulate collagen I, III, and IV — including a reported 25.4-fold increase in collagen IV synthesis in cell models when combined with low-molecular-weight hyaluronic acid at a 1:9 ratio.

Elastin & glycosaminoglycan production: Research indicates GHK-Cu stimulates elastin synthesis and supports structural integrity by inhibiting elastase activity, reducing the rate of elastin degradation.

Angiogenesis & vascular support: GHK-Cu acts as a pro-angiogenic signaling complex, stimulating VEGF expression and promoting endothelial cell migration in wound-model research.

Antioxidant & anti-inflammatory modulation: GHK-Cu has been studied for its capacity to regulate copper homeostasis, modify expression of antioxidant genes, suppress pro-inflammatory cytokines (TNF-α, IL-6), and protect keratinocytes from UVB-induced damage.

Matrix remodeling & gene expression: The peptide has been reported to influence the expression of a broad range of human genes associated with tissue repair, stemness, and extracellular matrix turnover.

Product specifications:

Compound: GHK-Cu (Copper Tripeptide-1)

CAS Number: 89030-95-5 (free peptide); 300801-03-0 (acetate form)

Molecular Formula: C₁₄H₂₂CuN₆O₄ (1:1 complex)

Molecular Weight: 401.91 g/mol (1:1 Cu complex)

Appearance: Blue crystalline powder

Purity: ≥98% by HPLC-UV (batch-specific COA; high-purity lots may exceed 99%)

Copper Content: 8.0–16.0% (ICP-MS verified for 1:1 stoichiometry)

Identity Confirmation: LC-MS (mass spectrometry)

Solubility: ≥100 mg/mL in H₂O

Storage: −20°C, protected from light and moisture

Quick answers

What does a 50mg GHK-Cu vial cover?

Injectable systemic protocols at 1-2mg weekly run for well over a month on this vial; reconstitute cold, use within thirty days. Topical-vs-injectable strategy, copper-loading caution and cycle length are covered in the GHK-Cu category notes.

How long until skin or hair changes show?

Skin texture: six to eight weeks of consistent use. Hair follicle cycling: three to six months - follicles move on their own clock, the copper only keeps the signal fed. Manage the timeline before judging the vial.

Any copper toxicity concern?

At chronic endless dosing, real ones exist - cycle four to eight weeks, do not stack topical and injectable indefinitely, and keep it alongside repair peptides like BPC-157 rather than doubling copper routes.