MOTS-c 10 mg

MOTS-c 10 mg is Hilma Biocare's mitochondrial-derived peptide, supplied as a single lyophilised vial. It is studied as a metabolic regulator that activates AMPK and influences insulin sensitivity and fatty-acid oxidation.

What MOTS-c Is

MOTS-c is a sixteen-amino-acid peptide encoded in mitochondrial DNA rather than the nuclear genome, which makes it unusual among research peptides. It is produced in mitochondria and can travel to the nucleus, where it influences gene expression. Its metabolic effects have led to comparisons with exercise, and it is one of the most researched peptides in the longevity and metabolic-health space. The 10 mg vial is the standard presentation.

The History of MOTS-c

MOTS-c was discovered in 2015 by researchers at the University of Southern California, who identified it while searching mitochondrial DNA for functional small peptides. The finding was significant because it showed that mitochondria produce signalling peptides, not just energy. Subsequent studies established its role in AMPK activation and metabolic regulation, and it quickly became a focus in ageing research.

How It Works

MOTS-c enters cells and activates AMPK, the energy-sensing kinase that shifts metabolism toward fatty-acid oxidation and glucose uptake. It also translocates to the nucleus under metabolic stress and regulates genes involved in antioxidant defence and mitochondrial function. The peptide improves insulin sensitivity in animal models and is studied as an exercise mimetic. Its short half-life means frequent administration in research.

What the Research Shows

• The 2015 discovery paper established MOTS-c as a mitochondrial-derived peptide.
• Animal studies show improved insulin sensitivity and reduced fat mass.
• Research demonstrates AMPK activation and increased fatty-acid oxidation.
• Age-related decline in MOTS-c has been reported in several models.

Research Context

MOTS-c has become a model for mitochondrial signalling research. Its discovery showed that mitochondria encode functional peptides, not just components of the respiratory chain. Studies in mice show that MOTS-c levels fall with age and that administration improves insulin sensitivity and exercise capacity. Researchers have described it as an exercise mimetic because many of its effects overlap with those of physical activity. Human data is still limited, but the mitochondrial origin of the peptide has made it a focus in ageing and metabolic disease research.

Strength, Pack and Authentication

Each vial contains 10 mg of lyophilised MOTS-c, sealed and packed in a printed carton stating the compound, strength and vial count. A scratch-off security code inside the box links the pack to Hilma Biocare's records. The powder is stable before reconstitution and intended for research use only.

Buying MOTS-c Online

MOTS-c is one of the most searched mitochondrial peptides. If you are researching MOTS-c 10 mg, comparing metabolic peptides or looking to buy MOTS-c online from a trusted Hilma Biocare supplier, this page gives you the full specification, pack size, price and live stock status. Browse more Hilma Biocare longevity peptides at NotNatty.